Lee's Pharmaceutical Holdings Net Worth is234.0 $Million
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Istaroxime ((E,Z)-3-((2-aminoethoxy)imin)androstane-6,17-dione hydrochloride) is an investigational drug originally patented and developed by the italian pharmaceutical company Sigma-Tau. Istaroxime is now under development for treatment of acute decompensated heart failure by CVie Therapeutics, a Chinese pharmaceutical company owned by Lee's Pharmaceutical Holdings Limited that in July 2012 has acquired from Sigma-Tau the patents and rights on Istaroxime and related compounds. It is still in early-stage development, having been evaluated in phase two clinical trials. Istaroxime is an innovative medication as it is an effective treatment for both systolic and diastolic heart failure. Systolic heart failure is characterized by impaired ventricular emptying, caused by reduced contractility, and diastolic dysfunction is defined by defective ventricular filling, caused by the hearta??s inability to properly relax between beats. Intracellular calcium fluxes regulate both contraction and relaxation. Cardiac muscle cells from patients with heart failure show smaller amounts of peak calcium in their cytoplasm during contraction, and slower removal., The mishandling of intracellular calcium is often due to problems in the cellsa?? ability to mediate calcium influx, and sequestration of calcium back in the sarcoplasmic reticulum.,
Istaroxime is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase). Na+/K+ ATPase inhibition increases intracellular sodium levels, which reverses the driving force of the sodium/calcium exchanger, inhibiting calcium extrusion and possibly facilitating calcium entry. , Additionally, Istaroxime increases intracellular calcium by improving the efficacy by which intracellular calcium triggers sarcoplasmic reticulum calcium release, and by accelerating the inactivation state of L-type calcium channels, which allow for calcium influx. Together the changes in calcium hand

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